Related Experiment Video
Updated: Aug 29, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Estrogen and chronic daily headache
1Pain Evaluation & Treatment Institute, 5750 Centre Avenue, Pittsburgh, PA 15206, USA. MarcusD@anes.upmc.edu
Abstract:
Estrogen exerts a strong influence on episodic headaches, such as migraine and tension-type headache. A relationship between sex hormones and chronic daily headache (CDH) is less well established. However, similarities between episodic and CDH suggest that estrogen also may significantly influence CDH. Pathophysiologic studies of CDH identify neurochemical abnormalities similar to those influenced by estrogen in episodic headache, such as aberrant 5-hydroxytryptamine activity. In addition, gender differences in CDH prevalence in pediatric and adult populations support a hormonal influence. Few studies have evaluated the ability of gynecologic events, such as menses, to influence CDH.
Related Concept Videos
Disorders of the Female Reproductive System
Cushing Syndrome I: Introduction
Menopause
Hypertension III: Clinical Manifestations and Diagnostic Studies
Cytotoxic Edema: Pathophysiology
Oogenesis
