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Related Experiment Videos

The nuclear GTPase cycle: promoting peripheralization?

A M Tartakoff1, R Schneiter

  • 1Institute of Pathology, Case Western Reserve University School of Medicine, 2085 Adelbert Road, Cleveland, OH 44106, USA.

Trends in Cell Biology
|January 1, 1995
PubMed
Summary

A nuclear GTPase cycle, regulated by guanine-nucleotide-exchange factors, controls key cell functions. This cycle is proposed to regulate nucleoplasmic dispersive functions, explaining observed disruptions.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Ras-like GTPases act as cytoplasmic molecular switches.
  • Only one GTPase has been identified in the nucleus, with homologs across species.
  • These nuclear GTPases are regulated by guanine-nucleotide-exchange factors.

Purpose of the Study:

  • To propose a novel regulatory role for the nuclear GTPase cycle.
  • To explain observed cellular effects resulting from disruptions in this cycle.

Main Methods:

  • Literature review and synthesis of existing data on nuclear GTPases.
  • Theoretical proposal based on observed biological phenomena.

Main Results:

  • The nuclear GTPase cycle is implicated in mRNA transport, protein import, DNA replication, RNA processing, and cell cycle regulation.

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  • A proposed function of the nuclear GTPase cycle is the regulation of dispersive functions within the nucleoplasm.

    • Conclusions:

    • The nuclear GTPase cycle's role extends beyond known functions to include regulation of nucleoplasmic dispersive activities.
    • This proposed function provides a unifying explanation for various cellular effects observed upon disruption of the nuclear GTPase cycle.