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Related Experiment Videos

T-cell activation.

M Izquierdo1, D A Cantrell

  • 1The authors are at the Lymphocyte Activation Laboratory, ICRF Laboratories, PO Box 123, Lincoln's, Inn Fields, London, UK WC2A 3PX.

Trends in Cell Biology
|September 1, 1992
PubMed
Summary
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T-cell activation involves biochemical changes like increased calcium and kinase activity. This review details signaling pathways downstream of protein kinase C and protein tyrosine kinases, highlighting p21(ras) as a key signal integrator.

Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • T lymphocyte activation triggers rapid intracellular biochemical events.
  • Key early events include increased cytosolic calcium (Ca2+), protein kinase C (PKC) stimulation, and protein tyrosine kinase (PTK) regulation.

Purpose of the Study:

  • To review recent advancements in understanding T-cell signaling pathways.
  • To elucidate the signaling steps downstream of PKC and PTKs.
  • To present a model of T-cell receptor (TCR) signal transduction.

Main Methods:

  • Literature review of recent studies on T-cell signaling.
  • Analysis of biochemical pathways involved in T-cell activation.
  • Development of a conceptual model for signal integration.

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Main Results:

  • Identified critical signaling molecules and pathways downstream of PKC and PTKs.
  • Demonstrated the role of p21(ras) in integrating signals from the TCR.
  • Provided a framework for understanding TCR-mediated signal transduction.

Conclusions:

  • The GTP-binding protein p21(ras) plays a central role in integrating signal transduction pathways initiated by the T-cell receptor.
  • Understanding these downstream signaling events is crucial for comprehending T-cell function and regulation.