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Updated: Aug 3, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
Published on: June 6, 2017
Cyclin-dependent kinases: a new cell cycle motif?
1Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, PO Box 85800, San Diego, CA 92186-5800, USA.
Eukaryotic cell cycle progression is regulated by cyclin-dependent kinases (CDKs), a novel class of protein kinases. These CDKs interact with cyclins to control cell cycle checkpoints and substrate phosphorylation.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- Eukaryotic cell cycle control involves checkpoints.
- Novel protein kinases, cyclin-dependent kinases (CDKs), are implicated in this regulation.
- CDKs require binding to cyclins, which are synthesized and degraded cyclically.
Purpose of the Study:
- To review newly identified putative cyclin-dependent kinases.
- To discuss their potential roles in cell cycle regulation.
- To explore their interactions with cyclins.
Main Methods:
- Literature review of cloned and identified putative CDKs.
- Analysis of structural similarities to known CDKs like p34cdc2.
- Discussion of functional implications based on existing data.
Main Results:
- Several novel proteins resembling p34cdc2 have been identified.
- These proteins are potential regulators of the eukaryotic cell cycle.
- Potential cyclin partners for these new CDKs are being investigated.
Conclusions:
- Cyclin-dependent kinases are key regulators of the eukaryotic cell cycle.
- The identification of new CDKs expands our understanding of cell cycle control mechanisms.
- Further research is needed to elucidate the specific roles and cyclin interactions of these novel CDKs.
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