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Related Experiment Videos

Signal transduction pathways to apoptosis.

D J McConkey1, S Orrenius

  • 1Department of Cell Biology, Box 173, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Trends in Cell Biology
|October 1, 1994
PubMed
Summary

Signaling pathways like calcium (Ca2+) and protein kinase C can both promote and inhibit apoptosis. This review explores how these signal transduction systems mediate multiple cellular responses.

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Area of Science:

  • Cellular signaling
  • Apoptosis regulation
  • Signal transduction

Background:

  • Diverse signaling events regulate apoptosis across various model systems.
  • These events include cytosolic Ca(2+) rises, cAMP accumulation, and protein kinase C activation.
  • The role of signaling in apoptosis is context-dependent, with some signals promoting and others inhibiting the process.

Purpose of the Study:

  • To review the dual role of specific signaling pathways in apoptosis.
  • To propose explanations for how signal transduction systems mediate opposing cellular outcomes.
  • To consolidate understanding of complex cellular responses to signaling events.

Main Methods:

  • Literature review of studies on apoptosis regulation.
  • Analysis of signaling pathways involved in cell death.
  • Synthesis of data from diverse model systems.

Main Results:

  • Cytosolic Ca(2+) rises, cAMP accumulation, protein kinase C, protein tyrosine kinases, and ceramide production are key regulators of apoptosis.
  • The same signaling events can either promote or inhibit apoptosis depending on the cellular context.
  • Signal transduction systems exhibit plasticity in mediating cellular fate.

Conclusions:

  • Signal transduction pathways possess the capacity to orchestrate opposing cellular responses, such as apoptosis promotion or inhibition.
  • Understanding the context-dependent nature of these signals is crucial for deciphering cellular fate.
  • This review provides a framework for understanding the multifaceted roles of signaling in cellular regulation.

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