Neurotropic factors, retrograde axonal transport and cell signalling

In vitro studies have recently identified receptors and signal transduction systems for many neurotrophic factors. In vivo, however, target-derived factors act over distances that are too great to be accounted for by simple diffusion of factors or classical second messengers. The active translocation of neurotrophic factors from the axon to the cell body by receptor-mediated retrograde transport provides a means by which factors presented at distal sites may influence somal signal transduction. We hypothesize that retrograde transport of receptors and other receptor-associated proteins leads to signalling at the cell body.