Related Experiment Video
Updated: Aug 14, 2026

Generation of Induced Pluripotent Stem Cells from Muscular Dystrophy Patients: Efficient Integration-free Reprogramming of Urine Derived Cells
Published on: January 28, 2015
The emerging family of dystrophin-related proteins
D J Blake1, J M Tinsley, K E Davies
1Molecular Genetics Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK OX3 9DU.
Abstract:
Duchenne and Becker muscular dystrophies are caused by mutations in the gene encoding dystrophin, a component of the subsarcolemmal cytoskeleton. Dystrophin-related proteins are identical or homologous to the cysteine-rich and C-terminal domains of dystrophin. This part of dystrophin binds to a membrane-spanning glycoprotein complex in muscle. At least five dystrophin-related proteins are encoded by the Duchenne muscular dystrophy locus. These proteins are found in many non-muscle tissues where dystrophin is not expressed and they are thought to be membrane-associated. Two other dystrophin-related proteins--utrophin and an 87 kDa postsynaptic protein--are encoded by separate loci and, like dystrophin, they are components of the neuromuscular junction.
Related Concept Videos
Cytoskeletal Linker Proteins - Plakins
Cytoskeletal Accessory Proteins
Actin Polymerization and Cell Motility
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate.
Satellite Stem Cells and Muscular Dystrophy
Desmosomes
The Sarcomere
Each myosin...

