Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basal bodies and DNA.

K A Johnson1, J L Rosenbaum

  • 1Department of Biology, Yale University, New Haven, CT 06511, USA.

Trends in Cell Biology
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Centrioles, crucial for cell division and structure, have long been debated to contain nucleic acid. Recent research challenges the idea that these basal bodies harbor a specific chromosome, prompting a re-evaluation of their self-replication.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrastructural and biochemical analysis of a new mutation in Chlamydomonas reinhardtii affecting the central pair apparatus.

Protoplasma·2007
Same author

Intraflagellar transport balances continuous turnover of outer doublet microtubules: implications for flagellar length control.

The Journal of cell biology·2001
Same author

Localization of intraflagellar transport protein IFT52 identifies basal body transitional fibers as the docking site for IFT particles.

Current biology : CB·2001
Same author

Localization of calmodulin and dynein light chain LC8 in flagellar radial spokes.

The Journal of cell biology·2001
Same author

Flagellar radial spoke protein 3 is an A-kinase anchoring protein (AKAP).

The Journal of cell biology·2001
Same author

An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C. elegans ciliated sensory neurons.

Current biology : CB·2001

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Basal bodies/centrioles are fundamental cellular structures involved in cell division and cytoskeletal organization.
  • Their conservative replication and segregation during mitosis have fueled debate about their potential autonomy.
  • The search for nucleic acid, specifically DNA, within centrioles has been a long-standing, controversial topic.

Purpose of the Study:

  • To investigate the presence and role of nucleic acid within basal bodies/centrioles.
  • To critically evaluate previous findings suggesting centrioles harbor a specific chromosome.
  • To re-examine the autonomous nature of centrioles in light of new evidence.

Main Methods:

  • Review of recent investigations and experimental data.

Related Experiment Videos

  • Analysis of findings related to basal body/centriole replication and segregation.
  • Comparative study of cellular components in Chlamydomonas.

    • Main Results:

    • New data has emerged that challenges the conclusion of a chromosome residing within basal bodies.
    • The findings necessitate a re-evaluation of the autonomous, self-replicating entity model for centrioles.
    • The precise role and composition of nucleic acid in basal bodies remain an active area of investigation.

    Conclusions:

    • The presence of a specific chromosome within basal bodies of Chlamydomonas is now questioned.
    • Centrioles may not be entirely autonomous self-replicating entities as previously hypothesized.
    • Further research is required to fully understand the nucleic acid content and function within basal bodies/centrioles.