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Updated: Aug 10, 2026

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay
Published on: May 26, 2011
Recognition domains in assembly of oligomeric membrane proteins
1Department of Physiology, University of California at San Francisco, San Francisco, CA 94143-0444, USA.
Abstract:
Many integral membrane proteins, particularly receptors on the cell surface, are made up of several polypeptide chains. After translation and insertion into the ER membrane, these subunits must assemble into the mature protein. However, the mechanisms controlling their faithful assembly are largely unknown. Recent evidence has shed some light on two cell surface receptors that use different strategies to assemble their subunits. Zach Hall discusses oligomerization of the T-cell receptor and the acetylcholine receptor.
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