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Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations
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A proliferation of cyclins

D J Lew1, S I Reed

  • 1Department of Molecular Biology, MB7, Scripps Research Institute, 10666 N. Torrey Pines Rd, La Jolla, CA 92037, USA.

Trends in Cell Biology
|March 1, 1992
PubMed

Insights

Cyclins, key cell cycle regulators, are a diverse protein family. This review focuses on the functions of newly discovered non-mitotic cyclins in yeast and mammalian cells.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Cyclins are essential regulatory subunits of serine/threonine protein kinases.
  • They play critical roles in the precise control of the cell cycle.
  • The cyclin protein family has recently expanded, revealing significant diversity.

Purpose of the Study:

  • To review the known functions of non-mitotic cyclins.
  • To highlight the expanding diversity within the cyclin protein family.
  • To discuss the roles of these cyclins in both yeast and mammalian cells.

Main Methods:

  • Literature review of recent studies on cyclins.
  • Analysis of functional data for newly identified cyclins.
  • Comparative analysis of cyclin functions across different species (yeast and mammalian cells).

Main Results:

  • The cyclin family is larger and more diverse than previously recognized.
  • Newly identified cyclins do not follow the classic "mitotic" cyclin accumulation and destruction pattern.
  • Non-mitotic cyclins exhibit varied functions in cell cycle regulation.

Conclusions:

  • The diversity of cyclins extends beyond their roles in mitosis.
  • Understanding non-mitotic cyclins is crucial for a comprehensive view of cell cycle control.
  • Further research is needed to fully elucidate the functions of these diverse proteins.

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