Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

P53 and breast cancer.

D Ziyaie1, T R Hupp, A M Thompson

  • 1Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK. dziyaie@hotmail.com

Breast (Edinburgh, Scotland)
|January 21, 2004
PubMed
Summary

The p53 tumor suppressor gene is frequently altered in human cancers, including breast cancer. Research is exploring p53

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enabling DCIS subtyping: leveraging foundation models for robust grading and molecular biomarker scoring.

NPJ breast cancer·2026
Same author

Corrigendum to "Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway" [The Veterinary Journal 196 (2013) 414-423].

Veterinary journal (London, England : 1997)·2021
Same author

Bridging the age gap in breast cancer: cluster randomized trial of two decision support interventions for older women with operable breast cancer on quality of life, survival, decision quality, and treatment choices.

The British journal of surgery·2021
Same author

Identifying triggers for hidradenitis suppurativa flare: a patient survey.

The British journal of dermatology·2021
Same author

Using observations and source specific model tracers to characterize pollutant transport during FRAPPÉ and DISCOVER-AQ.

Journal of geophysical research. Atmospheres : JGR·2020
Same author

Erythropoietin modulates striatal antioxidant signalling to reduce neurodegeneration in a toxicant model of Parkinson's disease.

Molecular and cellular neurosciences·2020

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The p53 tumor suppressor gene is the most frequently mutated gene in human cancers.
  • Mutations or alterations in p53 are observed in up to 50% of primary breast carcinomas.
  • Decades of research have elucidated the critical role of p53 in cancer development and progression.

Purpose of the Study:

  • To investigate the clinical utility of p53 as a biomarker in cancer.
  • To analyze the relationship between p53 expression and tumor development, progression, and patient outcomes.
  • To explore therapeutic strategies targeting the restoration of normal p53 function.

Main Methods:

  • Analysis of p53 mutation status in primary breast cancer.
  • Correlation studies between p53 expression levels and clinical parameters.
  • Investigation of novel treatment approaches aimed at p53 functional restoration.

Main Results:

  • p53 alterations are a common event in breast cancer, impacting patient outcomes.
  • p53 expression levels correlate with tumor development and progression.
  • Targeting p53 function represents a promising avenue for novel cancer therapies.

Conclusions:

  • p53 serves as a significant biomarker for predicting breast cancer progression and outcome.
  • Restoring normal p53 function holds therapeutic potential for breast cancer patients.
  • Further research into p53's clinical applications is warranted.

Related Experiment Videos