Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coronary endothelial dysfunction is not rapidly reversible with ascorbic acid.

Michael E Widlansky1, Elizabeth S Biegelsen, Naomi M Hamburg

  • 1Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.

Free Radical Biology & Medicine
|January 21, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinically-aligned explainable AI for atrial fibrillation detection: A U-Net inspired multi-lead ECG analysis framework.

Computer methods and programs in biomedicine·2026
Same author

Explainable artificial intelligence in electrocardiography: A systematic review.

Biomedical signal processing and control·2026
Same author

ALCAPA Diagnosed in an Elderly Patient.

JACC. Case reports·2025
Same author

Effects of pulmonary hypertension on right ventricular mechanics and coronary perfusion: Insights from computational simulations.

Computers in biology and medicine·2025
Same author

Chromatin interaction maps of human arterioles reveal mechanisms for the genetic regulation of blood pressure.

Nature communications·2025
Same author

Enhanced protein extraction and quantification protocol for microsamples: An ultra-sensitive workflow for low-volume, low-concentration total protein lysates.

Protein science : a publication of the Protein Society·2025
Same journal

Corrigendum to "Fatty acid oxidase Ehhadh mediates stem cell fate remodeling via mitophagy activation" [Free Radic. Biol. Med. 248 (2026) 109-126].

Free radical biology & medicine·2026
Same journal

HDL/ApoA1 attenuates atherosclerosis by suppressing macrophage ferroptosis via NRF2-SLC7A11-GSH axis activation.

Free radical biology & medicine·2026
Same journal

Salvianolic acid B mitigates neuronal ferroptosis after intracerebral hemorrhage in rats through a Piezo1-associated AMPK-mTOR pathway.

Free radical biology & medicine·2026
Same journal

Myeloid specific knockout of Piezo1 alleviates ang Ⅱ-induced cardiac remodeling.

Free radical biology & medicine·2026
Same journal

Microglia-derived exosomal miR-31-5p promotes type 2 diabetic retinopathy by impairing physiological angiogenesis homeostasis.

Free radical biology & medicine·2026
Same journal

GPX1 Drives Cuproptosis-Ferroptosis Resistance in Cold Tumors.

Free radical biology & medicine·2026
See all related articles

High doses of ascorbic acid did not improve endothelial dysfunction in patients with coronary atherosclerosis. This suggests superoxide anion is not a primary driver of this condition in these individuals.

Area of Science:

  • Cardiovascular Science
  • Vascular Biology
  • Oxidative Stress Research

Background:

  • Endothelial dysfunction in cardiovascular risk factors is linked to increased vascular superoxide anion production.
  • Superoxide anion can reduce nitric oxide bioavailability, impairing vasodilation.
  • Ascorbic acid (Vitamin C) is known to scavenge superoxide anions.

Purpose of the Study:

  • To investigate if increased superoxide anion contributes to endothelial dysfunction in atherosclerotic coronary arteries.
  • To determine the effect of ascorbic acid on coronary endothelial function in patients with coronary artery disease.

Main Methods:

  • 26 subjects undergoing cardiac catheterization received sequential infusions of ascorbic acid or placebo.
  • Coronary vasomotor function was assessed using intracoronary agonist infusion, quantitative angiography, and Doppler measurements.

Related Experiment Videos

  • Evaluated responses to acetylcholine and nitroglycerin before and during infusions.

    • Main Results:

    • Baseline endothelial-dependent vasodilation was similarly impaired in both groups.
    • Ascorbic acid infusions did not alter acetylcholine-induced changes in coronary artery diameter or blood flow compared to placebo.
    • Ascorbic acid also showed no effect on nitroglycerin-induced vasodilation.

    Conclusions:

    • These findings do not support a significant role for superoxide-mediated nitric oxide inactivation in coronary endothelial dysfunction in atherosclerosis.
    • Other mechanisms of oxidative stress may be more relevant in this patient population.