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Dengue diagnosis, advances and challenges
María G Guzmán1, Gustavo Kourí
1Virology Department, PAHO/WHO Collaborating Center for Viral Diseases, 'Pedro Kouri;' Tropical Medicine Institute, Autopista Novia del Mediodi;a, Km 6, Ciudad Habana, Cuba. lupe@ipk.sld.cu
Summary
Accurate dengue diagnosis requires accessible methods for early detection and prognosis. Advances like IgM capture ELISA and PCR exist, but improved infrastructure and expertise are crucial for global dengue control.
Area of Science:
- Tropical Medicine
- Infectious Diseases
- Diagnostic Technologies
Background:
- Dengue diagnosis was a key topic at the 2002 International Congress of Infectious Diseases symposium.
- The symposium highlighted the global threat posed by dengue fever.
Purpose of the Study:
- To review advances, problems, and challenges in dengue diagnosis.
- To identify needs for improved dengue diagnostic tools and infrastructure.
Main Methods:
- Review of existing dengue diagnostic techniques.
- Discussion of diagnostic methods presented at a 2002 symposium.
Main Results:
- Major advances include IgM capture ELISA, virus isolation, monoclonal antibodies, and PCR.
- A need persists for rapid, early, and accessible diagnostic methods for surveillance and clinical use.
- Tools for dengue prognosis are also needed for better patient management.
Conclusions:
- Despite advances, current dengue diagnostic methods have limitations.
- Enhanced laboratory infrastructure, technical expertise, and research capacity are essential in endemic regions.
- Improvements are vital for effective dengue surveillance, clinical management, and control strategies.