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Updated: Aug 29, 2026
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
Effects of high-frequency stimulation on subthalamic neuronal activity in parkinsonian patients
Marie-Laure Welter1, Jean-Luc Houeto, Anne-Marie Bonnet
1Centre d'Investigation Clinique, Fédération de Neurologie, Institut National de la Santé et de la Recherche Médicale Unit 289, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France.
Background:
High-frequency stimulation of the subthalamic nucleus (STN) is a neurosurgical alternative to medical treatment in levodopa-responsive forms of Parkinson disease. The mechanism of action of STN stimulation remains controversial, although an inhibition of overactive STN neurons has been postulated.
Objective:
To determine the effects of high-frequency STN stimulation on the neuronal activity of STN neurons in Parkinson disease patients.
Patients:
Single-unit recordings of the neuronal activity of the STN were obtained before, during, and after the application of intra-STN electrical stimulation in 15 Parkinson disease patients. Changes in firing frequency and pattern were analyzed using various combinations of stimulus frequency (range, 14-140 Hz).
Results:
Stimulation at a frequency greater than 40 Hz applied within the STN significantly decreased the firing frequency and increased the burst-like activity in the firing pattern of STN neurons. An aftereffect was observed in cells that had been totally inhibited during high-frequency stimulation.
Conclusion:
The beneficial effects of high-frequency stimulation result from a change in the firing pattern of cellular discharge and a blockade of the spontaneous overactivity of STN neurons.
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