Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Arterial stiffness and kidney function.

Michel E Safar1, Gérard M London, Gérard E Plante

  • 1Department of Internal Medicine, Hôpital Broussais, 96 rue Didot, 75674, Paris Cedex 14, France. michel.safar@brs.ap-hop-paris.fr

Hypertension (Dallas, Tex. : 1979)
|January 21, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mineral and bone metabolism markers and mortality in diabetic patients on haemodialysis.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2023
Same author

A case-control study indicates that coagulation imbalance is associated with arteriosclerosis and markers of endothelial dysfunction in kidney failure.

Kidney international·2020
Same author

Treatment-resistant hypertension in the hemodialysis population: a 44-h ambulatory blood pressure monitoring-based study.

Journal of hypertension·2020
Same author

Ethical challenges in nephrology: a call for action.

Nature reviews. Nephrology·2020
Same author

Sex Differences in Arterial Stiffening and Central Pulse Pressure: Mechanistic Insights?

Journal of the American College of Cardiology·2020
Same author

Arterial Stiffness in Hypertension and Function of Large Arteries.

American journal of hypertension·2020
Same journal

Brain Iron in Nucleus Accumbens and Cognitive Function in Preeclampsia.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Hypertension Treatment Intentions: A Health Belief Model Analysis.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Changes in Retinal Microvasculature During Healthy Pregnancy Measured by AO.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Longitudinal Maternal IgG and IgA Glycosylation Profiles in Pregnancy Reveal Early Immune Alterations in Placenta-Related Complications: The Rotterdam Periconception Cohort.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Blood Pressure Variability and Outcomes Across Antihypertensive Regimens.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Rural Health and Health Disparities in Hypertension Management: A Scientific Statement From the American Heart Association.

Hypertension (Dallas, Tex. : 1979)·2026
See all related articles

Increased aortic stiffness, a key feature in kidney disease, is linked to reduced kidney function (creatinine clearance). This association persists regardless of blood pressure or common risk factors, suggesting kidney disease impacts large arteries.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Vascular Biology

Background:

  • End-stage renal disease patients on hemodialysis exhibit increased aortic stiffness, independent of traditional cardiovascular risk factors.
  • Previous studies suggest a link between arterial stiffness and kidney function, particularly in younger populations and those with lower creatinine clearance.

Purpose of the Study:

  • To investigate the association between aortic stiffness and kidney function in patients with mild to severe renal insufficiency.
  • To determine if this association is independent of age, blood pressure, and other cardiovascular risk factors.
  • To examine the effect of antihypertensive drugs on aortic stiffness.

Main Methods:

  • Analysis of aortic pulse wave velocity and creatinine clearance.

Related Experiment Videos

  • Statistical assessment of associations, controlling for age, blood pressure, and cardiovascular risk factors.
  • Evaluation of the impact of angiotensin-converting enzyme inhibitors on aortic stiffness.

    • Main Results:

    • Aortic pulse wave velocity is statistically associated with creatinine clearance, independent of mean arterial blood pressure and classical risk factors.
    • This association is more pronounced in subjects younger than 55 years.
    • Angiotensin-converting enzyme inhibitors demonstrated a significant and independent effect in improving aortic stiffness.

    Conclusions:

    • Reduced creatinine clearance is independently associated with increased stiffness of central arteries in patients with renal insufficiency.
    • Kidney disease impacts both small and large arteries, irrespective of age, blood pressure, or common cardiovascular risk factors.
    • The roles of sodium, divalent ions, and the renin-angiotensin-aldosterone system in these alterations require further investigation.