Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dialysis without membranes: how and why?

Edward F Leonard1, Alan C West, Nina C Shapley

  • 1Department of Chemical and Biomedical Engineering, Columbia University, New York, NY 10027, USA.

Blood Purification
|January 21, 2004
PubMed
Summary

Membraneless dialysis, using flowing miscible fluids, offers faster transport and better biocompatibility. Challenges like pressure loss and material leakage are manageable with secondary processes and recycling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrating Sorbents in CO<sub>2</sub> Electroreduction: A Model System to Disentangle Layer Contributions in Membrane Electrode Assemblies.

Angewandte Chemie (International ed. in English)·2025
Same author

Nanoscopic Plugs Block Hydrogen Crossover in Submicron Thick Proton-Conducting SiO<sub>2</sub> Membranes for Water Electrolysis.

ACS nano·2025
Same author

Genetic Modification of <i>Acidithiobacillus ferrooxidans</i> for Rare-Earth Element Recovery under Acidic Conditions.

Environmental science & technology·2023
Same author

Overexpression of quorum sensing genes in <i>Acidithiobacillus ferrooxidans</i> enhances cell attachment and covellite bioleaching.

Biotechnology reports (Amsterdam, Netherlands)·2023
Same author

The Reductive Leaching of Chalcopyrite by Chromium(II) Chloride for the Rapid and Complete Extraction of Copper.

ChemistryOpen·2023
Same author

Gradient Architecture Design in Scalable Porous Battery Electrodes.

Nano letters·2022

Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Separation Science

Background:

  • Conventional dialysis relies on membranes, which can limit transport rates and biocompatibility.
  • Membraneless dialysis offers potential advantages in efficiency and patient comfort.

Purpose of the Study:

  • To quantify the advantages and disadvantages of membraneless dialysis.
  • To evaluate methods for overcoming the challenges associated with this technique.
  • To explore its applicability in other blood purification tasks.

Main Methods:

  • Establishing stable, sheathed fluid flows of miscible fluids.
  • Quantifying transport rates and material losses.
  • Theoretical analysis of molecular exchange.

Related Experiment Videos

Main Results:

  • Stable, sheathed fluid flows were achieved.
  • Molecular exchange was orderly and aligned with theoretical predictions.
  • Key challenges like pressure loss and potential material leakage were identified.

Conclusions:

  • Membraneless separations are feasible and offer enhanced transport and biocompatibility.
  • Overcoming disadvantages requires a secondary process and a recycle stream.
  • Potential applications extend to liver failure treatment and macromolecular separations.