Related Experiment Video

Updated: Aug 29, 2026

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
06:03

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

Gene therapy for lung cancer

P J Mosca1, M A Morse, T A D'Amico

  • 1Department of General and Thoracic Surgery, Duke University Medical Center, Durham, NC 27710, USA.

Clinical Lung Cancer
|January 22, 2004
PubMed

Insights

Gene therapy shows promise for lung cancer treatment. Early clinical trials indicate safety, but efficacy as a primary or adjunctive therapy requires further investigation.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Lung cancer remains a leading cause of cancer-related mortality worldwide.
  • Conventional treatments for lung cancer have limitations and significant side effects.
  • Gene therapy offers a novel approach to target cancer cells specifically.

Purpose of the Study:

  • To review the current landscape of gene therapy strategies for lung cancer.
  • To evaluate the preclinical and clinical evidence supporting gene therapy in lung cancer.
  • To assess the safety and potential efficacy of gene therapy for lung cancer patients.

Main Methods:

  • Review of in vitro and in vivo studies investigating gene therapy for lung cancer.
  • Analysis of data from Phase I and II clinical trials of gene therapy in lung cancer.
  • Examination of diverse gene therapy delivery systems and therapeutic targets.

Main Results:

  • Numerous gene therapy strategies have demonstrated promising results in preclinical lung cancer models.
  • Early-phase clinical trials suggest that gene therapy can be safely administered to lung cancer patients.
  • Specific gene therapy approaches have shown preliminary signs of efficacy.

Conclusions:

  • Gene therapy is an emerging and promising treatment modality for lung cancer.
  • Current evidence supports the safety of gene therapy in lung cancer patients.
  • Further research is needed to establish the definitive efficacy of gene therapy as primary or adjunctive lung cancer treatment.

More Related Videos

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Related Concept Videos

Gene Therapy01:22

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy01:22

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.