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Updated: Aug 6, 2026

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
Published on: February 19, 2019
[De novo hepatitis B with anti-HBc negative in a liver transplant recipient [corrected]]
J Campos Franco1, E Otero Antón, A González Quintela
1Servicio de Medicina Interna, Hospital Clínico Universitario, Santiago de Compostela, La Coruña, España. xkampos@hotmail.com
Abstract:
De novo hepatitis B was diagnosed in a 47-year-old man 15 months after liver transplantation for end-stage alcoholic cirrhosis. Serum antibodies to hepatitis B core antigen (anti-HBc) were negative, and remained undetectable over 20 months of follow-up. The possible causes of negative serum anti-HBc despite of active hepatitis B virus infection are reviewed. Immunosuppression may underlie this phenomenon in similar cases.
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