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Updated: Aug 29, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
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Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

Recent developments in MHC-class-I-mediated antigen presentation

Paul J Lehner1, Peter Cresswell

  • 1Lab 5.19, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Rd, CB2 2XY Cambridge, UK. pjl30@cam.ac.uk

Current Opinion in Immunology
|January 22, 2004
PubMed

Defective ribosomal products provide an important supply of endogenous peptides for entry into the classic MHC class I antigen presentation pathway. The recruitment of endoplasmic reticulum membrane during phagosome biogenesis allows exogenous antigens to be translocated into the cytosol as well as providing access to the class I peptide transport and loading machinery. This combination of features provides a mechanism for cross-presentation by specialised antigen presenting cells. Recent studies have shed new light on these pathways and have also described the emerging K3 family of viral ubiquitin E3 ligases, which constitutively ubiquitinate and degrade MHC class I molecules and other immunoreceptors.

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