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MHC class II signaling in antigen-presenting cells

Reem Al-Daccak1, Nuala Mooney, Dominique Charron

  • 1Institut Universitaire d'Hématologie, IFR105, Hôpital Saint Louis AP-HP, 10 rue Claude Vellefaux, 75475 Paris, France. Reem.Al-Daccak@bhdc.jussieu.fr

Current Opinion in Immunology
|January 22, 2004
PubMed

The MHC class II molecules have been recognized as signaling receptors for more than a decade, and recent work has revealed the importance of their signaling for the immune response. Today, we know that the function of MHC class II molecules on antigen-presenting cells (APCs) is not limited to their role as antigen-presenting structures; they are flexible receptors that, by triggering a variety of signaling pathways, can regulate APC activities from proliferation and maturation to apoptosis. Recent advances have provided insights into how these molecules might accommodate such regulation.

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