Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CYP2E1: from ASH to NASH.

Charles S. Lieber1

  • 1Section of Liver Disease and Nutrition, Bronx VA Medical Center (151-2), Mt. Sinai School of Medicine, 130 West Kingsbridge Road, 10468, Bronx, NY, USA

Hepatology Research : the Official Journal of the Japan Society of Hepatology
|January 22, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Prospective Seroepidemiological Study of Hepatitis E Virus Infection in an Occupational Health-Checkup Cohort in Mie Prefecture, Japan.

Hepatology research : the official journal of the Japan Society of Hepatology·2026
Same journal

Statin Use Is Associated With Improved Survival But Not Progression-Free Outcomes in Patients With Unresectable Hepatocellular Carcinoma Receiving Atezolizumab-Bevacizumab.

Hepatology research : the official journal of the Japan Society of Hepatology·2026
Same journal

Response to the Letter Regarding "Efficacy and Safety of Hypofractionated Radiation Therapy Combined With Immunotherapy for Hepatocellular Carcinoma With Vp4 Portal Vein Tumor Thrombosis".

Hepatology research : the official journal of the Japan Society of Hepatology·2026
Same journal

Hepatitis B Virus Infection Status in Japanese Children Prior to Universal Vaccination: Sustained Effectiveness of Mother-to-Child Transmission Prevention and Residual Infection Burden.

Hepatology research : the official journal of the Japan Society of Hepatology·2026
Same journal

Treatment Interval as a Prognostic Marker in Patients Undergoing Repeated Curative-Intent Local Treatment for Recurrent Hepatocellular Carcinoma.

Hepatology research : the official journal of the Japan Society of Hepatology·2026
Same journal

Comment on "The Advanced Lung Cancer Inflammation Index as a Prognostic Indicator in Patients With Unresectable Hepatocellular Carcinoma Receiving Atezolizumab and Bevacizumab Therapy".

Hepatology research : the official journal of the Japan Society of Hepatology·2026

Cytochrome P450 2E1 (CYP2E1) induction is a common mechanism in alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH). This enzyme

Area of Science:

  • Hepatology
  • Biochemistry
  • Toxicology

Background:

  • Alcoholic steatosis and steatohepatitis (ASH) share pathological similarities with nonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH).
  • These similarities suggest a common underlying pathogenic mechanism.

Purpose of the Study:

  • To identify and elucidate the common pathogenic mechanisms linking ASH and NASH.
  • To investigate the role of cytochrome P450 2E1 (CYP2E1) in liver disease.

Main Methods:

  • Review of studies over the last three decades investigating potential pathogenic mechanisms.
  • Focus on the induction of cytochrome P450 2E1 (CYP2E1) as a common link.

Main Results:

  • CYP2E1 induction is identified as a common mechanism in both ASH and NASH.

Related Experiment Videos

  • CYP2E1 substrates (fatty acids, ketones, ethanol) induce enzyme activity, leading to free radical release, lipid peroxidation, and mitochondrial damage.
  • This process exacerbates oxidative stress and can convert xenobiotics into toxic metabolites, promoting inflammation, fibrosis, and cirrhosis.

    • Conclusions:

    • Limiting inducers like excessive fatty acids (obesity) and alcohol is crucial for prevention.
    • Current pharmacologic treatments are lacking; research focuses on safe and effective CYP2E1 inhibitors.