Related Experiment Video
Updated: Aug 11, 2026
10:31
Real-time Live Imaging of T-cell Signaling Complex Formation
Published on: June 23, 2013
Coronin-1 expression in T lymphocytes: insights into protein function during T cell development and activation
Béatrice Nal1, Patrick Carroll, Elodie Mohr
1Centre d'Immunologie de Marseille-Luminy, INSERM-CNRS-Université de la Méditerranée, Case 906, 13288 Marseille Cedex 9, France.
International Immunology
|January 22, 2004
Summary
Coronin-1, an actin-binding protein, is present in mouse T lymphocytes throughout development. It accumulates in the cell cortex during T cell activation, suggesting a role in T cell dynamics.
Area of Science:
- Immunology
- Cell Biology
- Molecular Biology
Background:
- Coronin is an actin-binding protein involved in cell motility and division.
- Coronin-1 is found in mammals, with higher expression in hematopoietic tissues.
Purpose of the Study:
- To characterize Coronin-1 gene and protein expression in mouse T lymphocytes.
- To investigate the role of Coronin-1 in T cell development and activation.
Main Methods:
- Gene and protein expression analysis in T lymphocytes.
- Subcellular localization studies using microscopy.
- Analysis of T cell activation via TCR-CD3 stimulation.
Main Results:
- Coronin-1 is expressed throughout T cell ontogeny in embryonic and adult mice.
- Expression levels vary during thymic development, peaking in early thymocytes and selected single-positive thymocytes.
- Coronin-1 localizes to the cell cortex and accumulates in F-actin-rich membrane protrusions upon T cell activation.
Conclusions:
- Coronin-1 is dynamically regulated during T cell development and activation.
- Its localization suggests a role in T cell differentiation and activation processes involving actin cytoskeleton dynamics.
More Related Videos
Related Concept Videos
01:40Cell-mediated Immune Responses
Overview
01:16TGF - β Signaling Pathway
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
01:18Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
01:22T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:24B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...