![Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F3777.jpg&w=3840&q=50)
F-18 fluorodeoxyglucose uptake in atherosclerotic plaque in the mediastinum mimicking malignancy: another potential
Muzammil Z Hanif1, Munir Ghesani, Arshad A Shah
1Department of Nuclear Medicine, St Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA. muzammilhanif@yahoo.com
Abstract:
Atherosclerosis is an inflammatory process accumulating numerous inflammatory cells such as macrophages and lymphocytes. This cellular infiltrate has a high metabolic demand, which can be reflected on F-18 FDG positron emission tomographic (PET) imaging. The FDG uptake in atherosclerotic vessels is usually distinguishable as a result of its linear and continuous appearance and mild level of activity. However, occasionally, atherosclerotic plaques present themselves as focal "hot spots," which can be easily misinterpreted as malignancy. This report emphasizes atherosclerotic plaques as a potential pitfall while interpreting FDG scans. It also highlights the importance of radiographic correlation to avoid such an error.
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