Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrical-ionic control of gene expression.

J Vanden Broeck1, A De Loof, P Callaerts

  • 1Zoological Institute of the Katholieke Universiteit Leuven, Belgium.

The International Journal of Biochemistry
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>A20</i>/<i>TNFAIP3</i> heterozygosity predisposes to behavioral symptoms in a mouse model for neuropsychiatric lupus.

Brain, behavior, & immunity - health·2024
Same author

Evolutionary diversification of insulin-related peptides (IRPs) in aphids and spatiotemporal distribution in Acyrthosiphon pisum.

Insect biochemistry and molecular biology·2021
Same author

Lectin binding sites during Drosophila embryogenesis.

Roux's archives of developmental biology : the official organ of the EDBO·2017
Same author

Microarray-based annotation of the gut transcriptome of the migratory locust, Locusta migratoria.

Insect molecular biology·2016
Same author

Mood stabilizing drugs regulate transcription of immune, neuronal and metabolic pathway genes in Drosophila.

Psychopharmacology·2016
Same author

Glia in Drosophila behavior.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology·2014
Same journal

Intracellular localization of dinucleosideoligophosphate phosphorylase from Euglena gracilis.

The International journal of biochemistry·2010
Same journal

Specific phosphorylase from Euglena gracilis splits diadenosine 5',5'''-P(1),P(4)-tetraphosphate (Ap(4)A) and diadenosine 5',5'''-P(1),P(3)-triphosphate (Ap(3)A).

The International journal of biochemistry·2010
Same journal

Immunochemical homologies among L-alpha-hydroxyacid oxidase isozymes.

The International journal of biochemistry·2010
Same journal

Biochemical characterization of hemorrhagic toxin from Crotalus viridis viridis (prairie rattlesnake) venom.

The International journal of biochemistry·1994
Same journal

The 5'-sequence of the murine Hox-b3 (Hox-2.7) gene and its intron contain multiple transcription-regulatory elements.

The International journal of biochemistry·1994
Same journal

Characterization of human arylsulfatase A glycans.

The International journal of biochemistry·1994
See all related articles

Changes in cell ion environments influence gene expression by affecting cellular processes and protein interactions. Further research is needed to fully understand these complex mechanisms and their impact on cell-specific gene activity.

Area of Science:

  • Cellular and Molecular Biology
  • Biophysics
  • Genetics

Background:

  • Cellular physiological changes, including membrane potential and ionic activities, are linked to gene expression.
  • Intracellular ionic environments significantly influence cell-type-specific responses and gene regulation.
  • The precise mechanisms linking ionic changes to gene expression require further elucidation.

Purpose of the Study:

  • To explore the role of intracellular and intranuclear ionic environments in regulating gene expression.
  • To identify potential molecular targets affected by ionic changes.
  • To highlight the importance of understanding ionic homeostasis for gene regulation.

Main Methods:

  • Review of existing literature on ion transport, gene expression, and cellular signaling.

Related Experiment Videos

  • Analysis of studies investigating the impact of ionic environment on protein conformation, enzyme activity, and chromatin structure.
  • Discussion of emerging techniques for measuring intranuclear ion concentrations and gene localization.

    • Main Results:

    • Ionic environments affect various cellular components, including membranes, enzymes, proteins, chromatin, and the cytoskeleton, thereby modulating gene expression.
    • Intranuclear ionic composition can differ from the cytoplasm, challenging assumptions about nuclear envelope permeability.
    • Changes in protein phosphorylation are implicated in fine-tuning gene expression in response to ionic shifts.

    Conclusions:

    • Intracellular and intranuclear ionic environments play a critical role in regulating gene expression through diverse molecular mechanisms.
    • Understanding these ionic effects is crucial for comprehending cell-type-specific physiological responses.
    • Advances in gene cloning and localization techniques promise significant future insights into electrically controlled gene expression.