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Related Experiment Videos

Difficult-to-control asthma and obstructive sleep apnea.

Mordechai Yigla1, Naveh Tov, Anna Solomonov

  • 1Division of Pulmonary Medicine, Rambam Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. m_yigla@rambam.health.gov.il

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|January 23, 2004
PubMed
Summary

This study found a high prevalence of obstructive sleep apnea (OSA) in asthma patients on long-term oral corticosteroids. Continuous corticosteroid therapy was linked to more severe OSA, suggesting a role in airway collapsibility.

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Area of Science:

  • Pulmonology
  • Sleep Medicine
  • Pharmacology

Background:

  • Asthma is a chronic respiratory condition.
  • Obstructive sleep apnea (OSA) is a sleep disorder characterized by repeated upper airway collapse.
  • The relationship between asthma and OSA, particularly concerning corticosteroid use, requires further investigation.

Purpose of the Study:

  • To investigate the prevalence of OSA in patients with difficult-to-control asthma on long-term oral corticosteroid (CS) therapy.
  • To explore potential etiological factors linking asthma, CS use, and OSA.
  • To test the hypothesis that asthma promotes OSA.

Main Methods:

  • Prospective cohort study involving 22 severe unstable asthma patients undergoing polysomnography.
  • Patients received long-term oral corticosteroid therapy (continuous or bursts).

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  • Data collected included respiratory disturbance index (RDI), morphometric parameters, and a standard questionnaire.

    • Main Results:

    • A high prevalence of OSA (95.5%) was observed in the study group.
    • Mean RDI was 17.7, with significantly higher values in the continuous CS therapy subgroup (21.4 vs. 11.1).
    • Increased neck circumference during CS therapy did not significantly affect RDI.

    Conclusions:

    • Prolonged and continuous oral corticosteroid therapy in asthma patients is associated with a high prevalence of OSA.
    • Oral CS therapy may increase airway collapsibility, contributing to OSA development in asthma patients.
    • Further research is warranted to elucidate the mechanisms linking asthma, CS, and OSA.