Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dose-response study of thimerosal-induced murine systemic autoimmunity.

S Havarinasab1, L Lambertsson, J Qvarnström

  • 1Molecular and Immunological Pathology (AIR), Department of Molecular and Clinical Medicine, Linköping University, SE-581 85 Linköping, Sweden.

Toxicology and Applied Pharmacology
|January 23, 2004
PubMed
Summary

Thimerosal exposure in mice triggered autoimmune responses, including antibody production and immune complex deposition. This study clarifies thimerosal

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improved skin decontamination efficacy for the nerve agent VX.

Chemico-biological interactions·2020
Same author

Membranoproliferative glomerulonephritis and inflammatory pseudotumour of the spleen.

Case reports in oncology·2013
Same author

Workshop: Immunotoxicology and in vitro possibilities.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

Gold- and silver-induced murine autoimmunity--requirement for cytokines and CD28 in murine heavy metal-induced autoimmunity.

Clinical and experimental immunology·2008
Same author

High-density flexible interconnect for two-dimensional ultrasound arrays.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2008
Same author

Gold causes genetically determined autoimmune and immunostimulatory responses in mice.

Clinical and experimental immunology·2007

Area of Science:

  • Immunology
  • Toxicology
  • Environmental Health

Background:

  • Thimerosal, an organic mercury compound, is used as a disinfectant and preservative.
  • Concerns exist regarding thimerosal's potential health effects, particularly in childhood vaccines.
  • Thimerosal is a known sensitizing agent, rarely causing systemic immune reactions like acrodynia.

Purpose of the Study:

  • To investigate if thimerosal can induce systemic autoimmune conditions in genetically susceptible mice.
  • To compare the autoimmune response induced by thimerosal with that caused by inorganic mercury.

Main Methods:

  • A.SW mice were exposed to varying concentrations of thimerosal in drinking water for 70 days.
  • Assessed for antinucleolar antibodies (targeting fibrillarin), tissue immune-complex deposits, and serum immunoglobulin levels (IgE, IgG1, IgG2a).

Related Experiment Videos

  • Evaluated polyclonal B-cell activation and mercury concentrations in kidney and lymph nodes.

    • Main Results:

    • Thimerosal induced a dose-related development of antifibrillarin antibodies and tissue immune-complex deposits.
    • Significant dose-dependent increases in serum IgE, IgG1, IgG2a, and polyclonal B-cell activation were observed.
    • Thimerosal induced a systemic autoimmune syndrome in mice, similar to inorganic mercury but requiring higher doses.

    Conclusions:

    • Thimerosal induces a systemic autoimmune syndrome in genetically susceptible mice.
    • The induced autoimmune response is comparable to inorganic mercury but requires a higher absorbed dose.
    • The thimerosal-induced syndrome differs from reactions caused by methylmercury.