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Risk factors for malignancy in multinodular goitres.

A Ríos1, J M Rodríguez, M Canteras

  • 1Department of General Surgery and Digestive Apparatus I, Virgen de la Arrixaca University Hospital, El Palmar 30120, Murcia, Spain. arzrios@teleline.es

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|January 23, 2004
PubMed
Summary

Identifying risk factors for thyroid carcinoma in patients with multinodular goitre (MNG) is crucial. Key indicators include family history, prior cervical radiation, recurrent goitre, and cervical adenopathies, aiding early detection and management.

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Area of Science:

  • Endocrinology
  • Oncology
  • Surgical Pathology

Background:

  • Multinodular goitre (MNG) frequently co-occurs with thyroid carcinoma.
  • Risk factors for malignancy in MNG patients remain incompletely understood.
  • This study aimed to identify clinical risk factors for thyroid carcinoma in MNG.

Purpose of the Study:

  • To determine clinical risk factors associated with thyroid carcinoma in patients diagnosed with multinodular goitre.
  • To differentiate malignant from benign conditions within MNG cases.

Main Methods:

  • Analysis of a subgroup of 59 thyroid carcinoma cases from 672 MNG patients.
  • Variables assessed included demographics, medical history (radiation, surgery), goitre characteristics, and clinical findings.
  • Statistical analysis employed Chi-squared test, Student's t test, and logistic regression.

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Main Results:

  • Papillary carcinoma was the most common type (n=48), with 37 cases being microcarcinomas.
  • Independent risk factors for carcinoma included family history of thyroid pathology (RR=1.6), cervical radiation therapy (RR=1.8), recurrent goitre (RR=2.1), and cervical adenopathies (RR=1.6).

Conclusions:

  • Family history of thyroid pathology, prior cervical radiation, recurrent goitre, and cervical adenopathies are significant risk factors for malignancy in MNG.
  • These factors can aid in the clinical assessment and risk stratification of MNG patients.
  • Early identification of these risk factors may improve diagnostic accuracy and patient outcomes.