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[Antibiotic-associated diarrhea in the elderly].

G Kaltenbach1, D Heitz

  • 1Centre de gérontologie des hôpitaux universitaires de Strasbourg, hôpital de la Robertsau, 83, rue Himmerich, 67091 Strasbourg, France. georges.kaltenbach@chru-strasbourg.fr

La Revue De Medecine Interne
|January 23, 2004
PubMed
Summary

Antibiotic-associated diarrhea (AAD) can cause dehydration in the elderly. Probiotics may help restore gut flora balance, offering an economically impactful solution for this vulnerable population.

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Pharmacology

Context:

  • Antibiotic-associated diarrhea (AAD) affects 5-25% of patients, often due to intestinal flora disruption.
  • While most AAD resolves post-antibiotics, frail elderly individuals risk dehydration and malnutrition.
  • Clostridium difficile infection is a primary concern in elderly patients with severe AAD, especially those on beta-lactam antibiotics.

Purpose:

  • To highlight the risks of AAD in the elderly and the need for better management strategies.
  • To discuss the role of various pathogens in AAD, including Clostridium difficile, Staphylococcus aureus, and Klebsiella oxytoca.
  • To emphasize the importance of considering non-pathogenic organisms for restoring gut flora balance.

Summary:

  • AAD incidence varies by antibiotic, with C. difficile being a significant cause in the elderly.
  • Diagnostic focus for severe AAD in the elderly is C. difficile toxin detection.
  • Prevention involves judicious antibiotic use and enhanced hygiene to limit pathogen transmission.

Impact:

  • Improved understanding of AAD etiology and risk factors in elderly patients.
  • Potential for cost-effective interventions through the use of probiotics.
  • Enhanced strategies for AAD prevention and management in vulnerable populations.

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