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Related Experiment Videos

Fentanyl for sedation during upper gastrointestinal endoscopy.

S Ishido1, Y Kinoshita, N Kitajima

  • 1Department of Medicine, Miki City Hospital, Miki Hyogoken, Japan.

Gastrointestinal Endoscopy
|November 1, 1992
PubMed
Summary

Intravenous fentanyl sedation improved patient tolerance during gastroduodenoscopy. It reduced the rise in heart rate-blood pressure product and cortisol levels without negatively impacting oxygen saturation.

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Area of Science:

  • Anesthesiology
  • Gastroenterology
  • Cardiology

Background:

  • Gastroduodenoscopy can induce physiological stress.
  • Sedation is often used to improve patient comfort and tolerance during endoscopic procedures.

Purpose of the Study:

  • To evaluate the effects of intravenous fentanyl sedation on physiological parameters during gastroduodenoscopy.
  • To compare outcomes between patients receiving fentanyl and a control group.

Main Methods:

  • A randomized controlled trial involving 84 patients undergoing gastroduodenoscopy.
  • Patients were assigned to receive either intravenous fentanyl or no sedative (control group).
  • Monitored parameters included rate-pressure product, arterial oxygen saturation, electrocardiographic changes, and serum cortisol concentration.

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Main Results:

  • Fentanyl administration significantly increased patient tolerance for the procedure.
  • Fentanyl attenuated the endoscopy-induced increase in rate-pressure product (cardiac oxygen consumption) and serum cortisol levels.
  • No significant difference in arterial oxygen saturation was observed between the fentanyl and control groups.

Conclusions:

  • Intravenous fentanyl is a favorable sedative for upper gastrointestinal endoscopy.
  • Fentanyl enhances patient tolerance and reduces physiological stress responses during gastroduodenoscopy.
  • Fentanyl provides adequate sedation with minimal impact on oxygenation.