Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serial magnetization transfer imaging in acute optic neuritis.

S J Hickman1, A T Toosy, S J Jones

  • 1NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.

Brain : a Journal of Neurology
|January 23, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-HBs Immune Complex Levels: A Novel Marker of Hepatitis Flare Following Nucleos(t)ide Analog Withdrawal in HBeAg-negative Chronic Hepatitis B.

The Journal of infectious diseases·2025
Same author

Balancing Efficiency and Accuracy in Hepatitis C Rapid Antibody Testing: Insights From a Cluster Randomised Crossover Trial.

Journal of viral hepatitis·2025
Same author

Editorial: Ultralow HBsAg Levels and the Prediction of Cure in Chronic Hepatitis B.

Alimentary pharmacology & therapeutics·2025
Same author

New insights into the effects of ethylene on ABA catabolism, sweetening and dormancy in stored potato tubers.

Postharvest biology and technology·2021
Same author

Direct Measurement of Single-Molecule Ligand-Receptor Interactions.

The journal of physical chemistry. B·2020
Same author

Prevalence of baseline HCV NS5A resistance associated substitutions in genotype 1a, 1b and 3 infection in Australia.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2019
Same journal

Timing the Alzheimer's disease pathological cascade.

Brain : a journal of neurology·2026
Same journal

The significance of electrophysiological recordings from the bed nucleus of the stria terminalis in humans.

Brain : a journal of neurology·2026
Same journal

Fus-depleted oligodendrocytes reduce neuronal damage and Alzheimer's disease progression in the AppNL-G-F mouse.

Brain : a journal of neurology·2026
Same journal

Cervical lymph node biomarkers in neurodegeneration.

Brain : a journal of neurology·2026
Same journal

Lower motor neuron disorders: time for a closer look.

Brain : a journal of neurology·2026
Same journal

Reply: Cervical lymph node biomarkers in neurodegeneration.

Brain : a journal of neurology·2026
See all related articles

Magnetization transfer ratio (MTR) changes in acute optic neuritis reflect tissue integrity, mirroring multiple sclerosis lesions. MTR monitoring can track demyelinating lesions and recovery.

Area of Science:

  • Neuroimaging
  • Demyelinating Diseases

Background:

  • Reductions in Magnetization Transfer Ratio (MTR) in multiple sclerosis lesions indicate demyelination and axonal loss.
  • Later increases in MTR are attributed to remyelination.
  • MTR is a potential biomarker for tissue integrity in neurological conditions.

Purpose of the Study:

  • To investigate serial changes in MTR in acute optic neuritis.
  • To correlate MTR changes with clinical and electrophysiological measurements.
  • To validate MTR as a marker of tissue integrity in demyelinating lesions.

Main Methods:

  • Twenty-nine patients with acute optic neuritis and 27 controls underwent serial optic nerve imaging using fat-saturated fast spin echo (FSE) and magnetization transfer sequences.
  • Clinical examinations and visual evoked potentials (VEP) were recorded.

Related Experiment Videos

  • Lesion MTR was analyzed relative to healthy nerve MTR over one year.

    • Main Results:

    • Diseased optic nerve MTR and lesion ratio declined over time, reaching a nadir around 240 days.
    • A subsequent rise in MTR was observed, though not significantly different from the nadir at one year.
    • Improved visual acuity and VEP latency correlated with MTR values.

    Conclusions:

    • The early MTR fall suggests demyelination and axonal degeneration.
    • The delayed nadir may be due to slow myelin debris clearance, with later changes potentially reflecting remyelination.
    • MTR is a valuable tool for monitoring symptomatic demyelinating lesions.