Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[klotho gene].

Yuichiro Saito1, Masahiko Kurabayashi, Ryozo Nagai

  • 1Department of Pathophysiology and Internal Medicine, Gunma University Graduate School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 24, 2004
PubMed
Summary

The klotho gene, crucial for suppressing aging, improves endothelial dysfunction and nitric oxide production in mice. Klotho gene therapy shows potential for treating vascular issues like atherosclerosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted deep sequencing analyses of long QT syndrome in a Japanese population.

PloS one·2022
Same author

Short-Term Exposure to Sulfur Dioxide and Nitrogen Monoxide and Risk of Out-of-Hospital Cardiac Arrest.

Heart, lung & circulation·2022
Same author

Novel CACNA1C R511Q mutation, located in domain Ⅰ-Ⅱ linker, causes non-syndromic type-8 long QT syndrome.

PloS one·2022
Same author

Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart.

Scientific reports·2022
Same author

Peripheral Venous Pressure-Assisted Exercise Stress Echocardiography in the Evaluation of Pulmonary Hypertension During Exercise in Patients With Suspected Heart Failure With Preserved Ejection Fraction.

Circulation. Heart failure·2022
Same author

Impact of left atrial enlargement on image quality in coronary computed tomography angiography.

Clinical imaging·2022

Area of Science:

  • Genetics and Molecular Biology
  • Cardiovascular Research
  • Aging Research

Background:

  • The klotho gene suppresses multiple aging phenotypes.
  • Klotho deficiency in mice leads to endothelial dysfunction and reduced nitric oxide production.
  • Klotho gene expression decreases under circulatory and metabolic stress, such as in atherosclerosis.

Purpose of the Study:

  • To investigate the role of the klotho gene in endothelial function and its therapeutic potential in atherosclerosis.
  • To determine if klotho gene delivery can ameliorate endothelial dysfunction.

Main Methods:

  • Studied klotho gene-deficient mice to assess endothelial function and nitric oxide levels.
  • Investigated the effect of klotho gene delivery on endothelial dysfunction in a mouse model.

Main Results:

  • Klotho-deficient mice exhibited impaired aortic relaxation and significantly reduced nitric oxide production.
  • Klotho gene delivery improved endothelial dysfunction, involving nitric oxide pathways.
  • Klotho gene plays a role in modulating vascular function, including hypertension and vascular remodeling.

Conclusions:

  • Klotho gene is vital for maintaining endothelial function and nitric oxide homeostasis.
  • Klotho gene delivery demonstrates therapeutic potential for atherosclerotic disease and related vascular conditions.

Related Experiment Videos