Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet function in chronic leukemias.

K N Naresh1, P Sivasankaran, A J Veliath

  • 1Department of Pathology, Jawaharlal Institute of Post- Graduate Medical Education and Research, Pondicherry.

Indian Journal of Cancer
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to: Lovastatin inhibits adipocyte-associated increased proliferation, EMT and aggressiveness of breast cancer cells.

Medical oncology (Northwood, London, England)·2026
Same author

Lovastatin inhibits adipocyte-associated increased proliferation, EMT and aggressiveness of breast cancer cells.

Medical oncology (Northwood, London, England)·2025
Same author

A Systematic Approach to Prioritise Diagnostically Useful Findings for Inclusion in Electronic Health Records as Discrete Data to Improve Clinical Artificial Intelligence Tools and Genomic Research.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025
Same author

Structural insights into the interaction between molluscan hemocyanins and phenolic substrates: An in silico study using docking and molecular dynamics.

Journal of molecular graphics & modelling·2015
Same author

Primary cervical lymphoma: a rare presentation to a genitourinary medicine clinic.

International journal of STD & AIDS·2013
Same author

Purification, spectroscopic characterization and o-diphenoloxidase activity of hemocyanin from a freshwater gastropod: Pila globosa.

The protein journal·2013
Same journal

News in oncology.

Indian journal of cancer·2026
Same journal

Unveiling the rare, interesting series of malignant mesenchymal tumors of the kidney in a regional cancer care institute in South India.

Indian journal of cancer·2026
Same journal

Why our unison matters: Head and neck cancer care providers.

Indian journal of cancer·2026
Same journal

District cancer control program: A white paper to optimize cancer care in rural India by developing a uniform, modular, and multi-tier system.

Indian journal of cancer·2026
Same journal

PI-RADS v2 score may be as a predictor of bone metastasis in prostate cancer.

Indian journal of cancer·2026
Same journal

Evaluation of sexual life quality and vaginal dose-volume relationship in female rectal cancer patients treated with pelvic radiotherapy.

Indian journal of cancer·2026
See all related articles

This study investigated platelet function in 12 chronic leukemia patients, finding abnormalities in all cases. Platelet aggregation was notably impaired across all chronic leukemia subtypes, impacting bleeding risk.

Area of Science:

  • Hematology
  • Oncology
  • Platelet Physiology

Background:

  • Chronic leukemias, including chronic myeloid leukemia (CML) and chronic lymphatic leukemia (CLL), are associated with various hematological abnormalities.
  • Platelet dysfunction can contribute to bleeding complications in patients with hematological malignancies.

Purpose of the Study:

  • To evaluate platelet function in patients diagnosed with chronic leukemia.
  • To identify specific platelet defects in chronic myeloid leukemia and chronic lymphatic leukemia and related disorders.

Main Methods:

  • Assessed bleeding time, clot retraction, and platelet factor 3 (PF3) availability.
  • Measured platelet aggregation responses to adenosine diphosphate (ADP), epinephrine, collagen, and ristocetin.

Related Experiment Videos

Main Results:

  • All 12 chronic leukemia patients exhibited one or more platelet function abnormalities.
  • Platelet aggregation responses were significantly impaired in all evaluated cases.
  • Specific defects varied, with prolonged bleeding time, impaired clot retraction, and decreased PF3 availability observed in subsets of CML and CLL patients.

Conclusions:

  • Patients with chronic leukemia frequently present with diverse platelet function defects.
  • Impaired platelet aggregation is a consistent finding in chronic leukemia, potentially increasing bleeding risk.