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Plakolide A, a new gamma-lactone from the marine sponge Plakortis sp
Sarath P Gunasekera1, Richard A Isbrucker, Ross E Longley
1Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U.S. 1 North, Fort Pierce, FL 34946, USA. sgunaseker@hboi.edu
Journal of Natural Products
|January 24, 2004
Abstract:
Plakolide A (1), a new alpha-exomethylene-gamma-lactone isolated from the marine sponge Plakortis sp., was found to inhibit inducible nitric oxide synthase (iNOS) activity. The isolation, structure elucidation, and biological activity of plakolide A is described.

