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Effects of topically applied sulphur mustard on tissue glycogen, blood glucose, lactate and pyruvate in mice
K Sugendran1, K Jeevaratnam, K Husain
1Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior.
Abstract:
Bis-2-Chloroethyl sulphide, commonly known as sulphur mustard (SM) or mustard gas, an alkylating agent, is frequently used as a chemical warfare agent. Inhibition of glycolysis has been related to skin injury and cell death. The effects of SM on tissue glycogen, blood glucose, lactate/pyruvate ratio were investigated in the present study. After a single dermal application of 1.0 LD50 SM in mice, a significant hyperglycemia was observed at 24 hr post exposure. There was a corresponding decrease in liver glycogen content, with no alteration in glycogen content of brain, muscles and kidney. Blood pyruvate and lactate levels were not appreciably altered.