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Serum lipoprotein profile under different antihypertensive therapy

S Youssef1, L Osman, M S Sabbour

  • 1Department of Medicine and Clinical Pathology, Ain-Shams University Cairo, Egypt.

International Journal of Clinical Pharmacology Research
|January 1, 1992
PubMed

Insights

Enalapril and benazepril, used for hypertension, improved serum lipid profiles by increasing HDL-C and decreasing the total cholesterol/HDL-C ratio. These ACE inhibitors positively impacted the atherogenic ratio.

Area of Science:

  • Cardiology
  • Pharmacology
  • Biochemistry

Background:

  • Essential hypertension is a common condition requiring effective treatment.
  • Serum lipid profiles are crucial indicators of cardiovascular risk.
  • Antihypertensive medications can influence lipid metabolism.

Purpose of the Study:

  • To compare the effects of four antihypertensive therapies on serum lipid parameters.
  • To evaluate changes in high-density lipoprotein cholesterol (HDL-C) and the total cholesterol/HDL-C ratio.
  • To assess the impact on the atherogenic ratio in patients with essential hypertension.

Main Methods:

  • 80 patients with essential hypertension received enalapril, benazepril, Epitens, or isradipine for eight weeks.
  • A control group of 10 hypertensive patients received a placebo.
  • Serum lipid parameters, including HDL-C and the total cholesterol/HDL-C ratio, were measured post-therapy.

Main Results:

  • Enalapril significantly increased HDL-C and decreased the total cholesterol/HDL-C ratio.
  • Benazepril significantly decreased the total cholesterol/HDL-C ratio.
  • Both enalapril and benazepril significantly improved the atherogenic ratio; isradipine showed a lesser improvement, while Epitens caused insignificant deterioration.

Conclusions:

  • Angiotensin-converting enzyme inhibitors (enalapril, benazepril) demonstrate favorable effects on lipid profiles and the atherogenic ratio in hypertensive patients.
  • Calcium channel blockers (isradipine) also show some benefit, though less pronounced.
  • Diuretic combination therapy (Epitens) had minimal impact on electrolytes and a negative effect on the atherogenic ratio.

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