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Adhesins and invasins of pathogenic bacteria: a structural view
Hartmut H Niemann1, Wolf Dieter Schubert, Dirk W Heinz
1Department of Structural Biology, German Research Center for Biotechnology (GBF), Mascheroder Weg 1, 38124, Braunschweig, Germany.
Microbes and Infection
|January 24, 2004
Abstract:
Adhesion and invasion of pathogenic bacteria represent the important initial step of infection. Pathogens utilize surface-located adhesins/invasins for specific interaction with host cell receptors. The three-dimensional structures of a number of adhesins/invasins show that many are elongated molecules containing domains commonly found in eukaryotic proteins. Similar folds are employed repeatedly to target different receptors.