Related Experiment Video
Updated: Aug 8, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
In vitro study of some medicinally important Mannich bases derived from antitubercular agent
Sheela Joshi1, Navita Khosla, Prapti Tiwari
1School of Chemical Sciences, Devi Ahilya Vishwavidyalaya, Takshila campus, Khandwa road, Indore, India. spjoshi11@rediffmail.com
Abstract:
Biologically active Mannich bases with heteroaromatic ring system have been synthesised employing Mannich reaction of isonicotinyl hydrazide with various sulphonamides/secondary amines. They were analysed by elemental analysis and characterized by uv, ir, 1H nmr spectroscopic studies. The Mannich bases were screened for their antibacterial activity against various gram positive and gram negative bacteria and were analyzed statistically. The results have shown that the compounds are quiet active against pathogens under study and were nontoxic.

