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Related Experiment Videos

Haloperidol versus risperidone on rat "early onset" vacuous chewing.

Giorgio Marchese1, Francesco Bartholini, Maria Antonietta Casu

  • 1Neuroscienze S.c.ar.l., Via Palabanda 9, 09123, Cagliari, Italy. giorgio.marchese@ns.crs4.it

Behavioural Brain Research
|January 24, 2004
PubMed
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Haloperidol demonstrated a greater propensity to induce vacuous chewing movements (VCMs) in rats compared to risperidone. These findings suggest differences in their potential to cause extrapyramidal symptoms.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Subchronic antipsychotic treatment can induce "early onset" vacuous chewing movements (VCMs) in rats, serving as a model for human extrapyramidal symptoms.
  • Comparing the VCM-inducing propensities of different antipsychotics is crucial for understanding their side effect profiles.

Purpose of the Study:

  • To compare the propensity of haloperidol and risperidone to induce "early onset" vacuous chewing movements (VCMs) in rats.
  • To evaluate these effects after subchronic administration and varying withdrawal periods.

Main Methods:

  • Rats received subchronic (4 weeks) twice-daily administration of haloperidol (0.1-1mg/kg) or risperidone (1-10mg/kg) at doses inducing comparable acute catalepsy.
  • Vacuous chewing movements (VCMs) were assessed 12 hours, 5 days, and 3 weeks after drug withdrawal.

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Main Results:

  • Haloperidol (0.5 and 1mg/kg) induced significant VCMs at 12h and 5 days post-withdrawal, returning to basal levels by 3 weeks.
  • Risperidone (10mg/kg) induced VCMs only at 12h post-withdrawal, with no significant effect at later time points.

Conclusions:

  • Haloperidol exhibits a substantially higher propensity to induce "early onset" VCMs in rats compared to risperidone.
  • These findings highlight differential risks for extrapyramidal symptoms between these antipsychotics.