Related Experiment Video
Updated: Aug 29, 2026
Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
Published on: April 3, 2026
Tissue characterization identifies subjects with high risk of cardiovascular diseases
Naoto Katakami1, Yoshimitsu Yamasaki, Keisuke Kosugi
1Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Yamadaoka 2-2, Suita City, Osaka 565-0871, Japan.
Insights
Integrated backscatter (IBS) and intima-media thickness (IMT) of the carotid artery can identify diabetic patients with recent acute coronary syndrome (ACS) or atherothrombotic infarction (ATI), indicating high cardiovascular disease risk.
Area of Science:
- Vascular biology and imaging
- Cardiovascular disease risk stratification
- Diabetology
Background:
- Type 2 diabetes is a significant risk factor for cardiovascular diseases.
- Carotid artery plaque characteristics may predict future cardiovascular events.
- Integrated backscatter (IBS) and intima-media thickness (IMT) are ultrasound-derived measures of carotid artery wall tissue.
Purpose of the Study:
- To determine if carotid artery wall tissue characterization using IBS can identify diabetic patients with recent acute coronary syndrome (ACS) or atherothrombotic infarction (ATI).
- To assess the association between carotid plaque size (Max-IMT) and tissue characteristics (corrected-IBS) with cardiovascular events in diabetic patients.
Main Methods:
- Ultrasonographic measurement of maximum intima-media thickness (Max-IMT) and corrected integrated backscatter (corrected-IBS) in 132 type 2 diabetic subjects.
- Comparison of carotid artery parameters between diabetic patients with and without recent cardiovascular diseases (ACS/ATI).
- Logistic regression analysis to identify predictors of recent ACS or ATI.
Main Results:
- Diabetic patients with recent ACS or ATI exhibited significantly lower corrected-IBS and higher Max-IMT compared to those without cardiovascular diseases.
- The product of Max-IMT and corrected-IBS (IMT-IBS product) was significantly lower in patients with recent ACS compared to those with stable angina.
- The IMT-IBS product was the sole significant predictor of a recent history of ACS (OR 0.94) and ATI (OR 0.90).
Conclusions:
- Diabetic patients with a recent history of ACS or ATI demonstrate altered carotid artery wall characteristics, specifically lower IBS values and increased IMT.
- Both the size and tissue composition of carotid plaques, as assessed by the IMT-IBS product, are valuable in identifying diabetic individuals at high risk for cardiovascular disease events.
Objective:
This study was conducted to examine whether tissue characterization of the carotid artery wall by determining integrated backscatter (IBS) can identify subjects with a recent history of acute coronary syndrome (ACS) or atherothrombotic infarction (ATI).
Research Design And Methods:
The maximum thickness (Max-IMT) and IBS value (corrected-IBS) of the carotid artery intima-media complex were measured ultrasonographically for 132 type 2 diabetic subjects (62.9+/-8.5 (+/-S.D.) years old, 87 men and 45 women) with or without cardiovascular diseases.
Results:
The diabetic patients with recent ACS or ATI had a significantly lower corrected-IBS and higher Max-IMT than those with Max-IMT > or = 1.1mm but without cardiovascular diseases. The product of Max-IMT and corrected-IBS (IMT-IBS product) of the patients with recent ACS was significantly lower than that of the patients with chronic stable angina. The multiple logistic model showed that only the IMT-IBS product was associated with a recent history of ACS (odds ratio 0.94, P<0.05) and ATI (odds ratio 0.90, P<0.005).
Conclusions:
Diabetic patients who had a recent history of ACS or ATI showed a lower IBS value and higher IMT for their carotid artery. Both the size and tissue characteristics of the carotid plaque may identify subjects with a high risk of cardiovascular disease.
Related Concept Videos
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Coronary Artery Disease I: Introduction
01:23Assessment of the Cardiovascular System I: Subjective Data
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests