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Comparison of vascular opacification after bolus injection of iodixanol-320 iohexol-350
R Gould1, R C Brasch, R Sievers
1Department of Radiology, University of California San Francisco 94143.
Rationale And Objectives:
The vascular opacification characteristics of a new nonionic, dimeric contrast agent, iodixanol, have been compared with a nonionic, monomeric agent, iohexol, using ultrafast computed tomography (UFCT).
Methods:
In 10 experiments with mongrel dogs, the contrast agents were alternately injected into the animal's left atrium, and UFCT images were obtained at four cross-sectional levels through the carotid arteries. Time-density curves were then obtained for each carotid artery and each agent. The peak height and area under the curves were compared for each agent.
Results:
Iohexol provided significantly (P < or = .05) greater opacification, determined by paired Student's t tests.
Conclusion:
This result was predicted from the greater iodine concentration of iohexol (350 mg/mL) compared with iodixanol (320 mg/mL); the difference was greater than expected based on iodine content alone.