Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Correlation between plasma and urine phenylalanine concentrations.

Manal Boulos1, Olivier Boulat, Guy Van Melle

  • 1Département Médico-Chirurgical de Pédiatrie, Laboratoire de Chimie Clinique, Lausanne, Switzerland.

Biology of the Neonate
|January 24, 2004
PubMed
Summary

This pilot study suggests urine phenylalanine concentration can predict plasma levels in phenylketonuria patients, potentially replacing frequent blood tests with urinalysis. This could improve treatment adherence and cognitive development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Urinary protein to creatinine ratio during the first month of life in very preterm infants-a prospective cohort study (PROTIPREMA).

Pediatric nephrology (Berlin, Germany)·2022
Same author

Correction to: When the progresses in neonatology lead to severe congenital nephron deficit: is there a pilot in the NICU?

Pediatric nephrology (Berlin, Germany)·2022
Same author

When the progresses in neonatology lead to severe congenital nephron deficit: is there a pilot in the NICU?

Pediatric nephrology (Berlin, Germany)·2021
Same author

Use of diuretics in the neonatal period.

Pediatric nephrology (Berlin, Germany)·2021
Same author

Maturation of glomerular filtration rate in neonates and infants: an overview.

Pediatric nephrology (Berlin, Germany)·2020
Same author

Acute Renal Failure in the Neonate.

Journal of pediatric intensive care·2019

Area of Science:

  • Biochemistry
  • Metabolic Disorders
  • Clinical Diagnostics

Background:

  • Phenylketonuria (PKU) requires strict low-phenylalanine diet management.
  • Monitoring PKU treatment typically involves frequent, invasive blood sampling to measure plasma phenylalanine levels.
  • Current monitoring methods can impact patient compliance and quality of life.

Purpose of the Study:

  • To investigate the potential of using urine phenylalanine concentration to predict plasma phenylalanine levels in PKU patients.
  • To explore a less invasive monitoring method for PKU management.
  • To assess the feasibility of replacing blood sampling with urinalysis for PKU monitoring.

Main Methods:

  • Pilot study involving a small cohort of PKU patients.
  • Analysis of plasma and urine phenylalanine concentrations.

Related Experiment Videos

  • Development of a predictive model incorporating patient age.

    • Main Results:

    • A significant correlation was found between plasma and urine phenylalanine concentrations.
    • Patient age was identified as a crucial factor in the predictive model.
    • Urinalysis shows promise as a non-invasive surrogate for plasma phenylalanine measurement.

    Conclusions:

    • Plasma phenylalanine levels can be predicted from urine concentrations, considering patient age.
    • Urinalysis may offer a viable alternative to frequent blood sampling for PKU monitoring.
    • Further validation in larger, multicenter studies is necessary before clinical implementation.