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Related Experiment Videos

Growth hormone and aging.

C Ariznavarreta1, C Castillo, G Segovia

  • 1Department of Physiology, School of Medicine, Department of Cellular Biology, School of Biology, Complutense University, Madrid, Spain.

Homo : Internationale Zeitschrift Fur Die Vergleichende Forschung Am Menschen
|January 27, 2004
PubMed
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Aging impairs vascular and central nervous system functions, partly due to growth hormone (GH) deficiency. GH treatment in aged rats improved vascular responses and restored neuronal and neurotransmitter levels, suggesting therapeutic potential.

Area of Science:

  • Gerontology
  • Endocrinology
  • Neuroscience

Background:

  • Elderly individuals commonly experience vascular and central nervous system (CNS) degenerative changes, leading to significant morbidity and mortality.
  • Factors like lipid pattern modifications and menopause contribute to these age-related alterations.
  • Vascular homeostasis relies on the endothelium's production of vasoactive factors, which can be affected by aging and hormonal changes.

Purpose of the Study:

  • To investigate the effects of growth hormone (GH) on vascular and CNS functions in aged rats.
  • To clarify the role of physiological GH deficiency in age-related functional decline.
  • To evaluate GH's impact on endothelial function, neuronal populations, and neurotransmitter levels in vivo.

Main Methods:

Related Experiment Videos

  • A study using aged Wistar rats was conducted to assess GH's effects under chronic in vivo conditions.
  • Vascular responses to vasoactive substances were evaluated in aortic rings.
  • Neuronal counts in the hippocampus and neurotransmitter levels in cerebral areas were measured and compared between young, old, and GH-treated old rats.

    • Main Results:

    • Aged rats exhibited increased aortic media thickness and reduced vasodilator response to isoprenaline compared to young rats.
    • GH treatment partially restored vasodilator response and decreased aortic media thickness in aged rats.
    • GH administration significantly increased hippocampal neuronal populations and normalized neurotransmitter levels (glutamine, arginine, aspartate, citrulline) in aged rats.

    Conclusions:

    • Physiological GH deficiency in the elderly may contribute to vascular and cerebral dysfunction.
    • GH treatment demonstrated beneficial effects on vascular endothelium function and CNS integrity in aged rats.
    • GH therapy holds potential for mitigating age-related vascular and neurodegenerative changes.