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Updated: Jul 18, 2026

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish
Published on: July 16, 2012
Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research
Erwin W Gelfand1, Sireesh Appajosyula, Suzanne Meeves
1Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA. gelfande@njc.org
Objective:
To compare the anti-inflammatory effects of fexofenadine with other H(1)-receptor antagonists in vitro.
Data Sources:
Published literature.
Study Selection:
Recent experimental studies on anti-inflammatory effects of H(1)-receptor antagonists. Databases searched: Medline, Medscape.
Period Covered:
1990-2003. Search terms: second-, third-generation antihistamines; sedating, nonsedating antihistamines; in vitro anti-inflammatory activity; cetirizine; ebastine; loratadine; fexofenadine; desloratadine.
Results:
Second- and third-generation H(1)-receptor antagonists may demonstrate significant in vitro anti-inflammatory activity at concentrations considered to be clinically relevant. In some instances, higher (supraclinical) concentrations are required to achieve comparable effects.
Conclusions:
Experimental research suggests that second- and third-generation H(1)-receptor antagonists may achieve anti-inflammatory effects in a clinical context. Further studies are required to support this conclusion.
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