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PMWS: experimental model and co-infections.
G M Allan1, F McNeilly, J Ellis
1Virology Department, Veterinary Research Laboratory, Veterinary Sciences Division, Stoney Road Stormont, DARDNI, Stormont, BT4 SD Belfast, Northern Ireland, UK. gordon.allan@dardni.gov.uk
Veterinary Microbiology
|January 27, 2004
Summary
Porcine circovirus type 2 (PCV2) causes economically significant wasting disease in young pigs. Experimental infections confirm PCV2
Area of Science:
- Veterinary Pathology
- Swine Disease Research
- Virology
Background:
- Porcine circovirus type 2 (PCV2) is identified as the cause of porcine multisystemic wasting syndrome (PMWS).
- PMWS is an economically significant disease affecting young pigs.
- Gross and histological lesions associated with PMWS are well-documented.
Purpose of the Study:
- To review experimental PCV2 infections in different pig models.
- To consolidate findings from various research groups regarding PCV2 pathogenesis.
- To draw conclusions about PCV2 infection based on experimental data.
Main Methods:
- Experimental infection of gnotobiotic (GN) pigs with PCV2.
- Experimental infection of colostrum-deprived (CD) pigs with PCV2.
- Experimental infection of colostrum-fed (CF) pigs with PCV2.
Main Results:
- Detailed review of experimental infection outcomes.
- Analysis of clinical signs, gross lesions, and histological findings post-PCV2 infection.
- Comparison of disease progression in GN, CD, and CF pigs.
Conclusions:
- Experimental infections provide critical insights into PCV2 pathogenesis.
- Understanding PCV2 infection dynamics in different pig models aids in disease management.
- This review synthesizes current knowledge on PCV2-induced disease.