Related Experiment Video
Updated: Aug 29, 2026

Skin Tattooing As A Novel Approach For DNA Vaccine Delivery
Published on: October 18, 2012
Prior DNA vaccination does not interfere with the live-attenuated measles vaccine
Mary Premenko-Lanier1, Paul Rota, Gary Rhodes
1Department of Pathology, California National Primate Research Center, School of Medicine, University of California-Davis, County Road 98 and Hutchison Drive, Davis, CA 95616-8542, USA.
Abstract:
The currently used live-attenuated measles vaccine is very effective although maternal antibody prevents its administration prior to 6 months of age. We are investigating the ability of a DNA vaccine encoding the measles viral hemagglutinin, fusion and nucleoprotein to protect newborn infants from measles. Here, we show that a measles DNA vaccine protects juvenile macaques from pathogenic measles virus challenge and that macaques primed and boosted with this DNA vaccine have anemnestic antibody and cell-mediated responses after vaccination with a live-attenuated canine distemper-measles vaccine. Therefore, this DNA vaccine administered to newborn infants may not hinder the subsequent use of live-attenuated measles vaccine.
Related Concept Videos
Vaccinations
Poliomyelitis
Smallpox
Vaccines
Microorganisms in Medicine and Therapeutics
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...

