Related Experiment Video

Updated: Aug 29, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

Synthesis and biological evaluation of (-)-laulimalide analogues

Brian M Gallagher1, Francis G Fang, Charles W Johannes

  • 1Eisai Research Institute, 100 Research Drive, Wilmington, MA 01887, USA. brian_gallagher@eri.eisai.com

Bioorganic & Medicinal Chemistry Letters
|January 27, 2004
PubMed

Abstract:

Analogues of the marine natural product (-)-laulimalide were prepared by total synthesis and evaluated in vitro for anticancer activity.

More Related Videos

Identification of Potential Anti-TB Candidates: A Step-by-Step Guide to Synthesis, MIC Determination, and Cytotoxicity Assessment in Mammalian Cells
10:24

Identification of Potential Anti-TB Candidates: A Step-by-Step Guide to Synthesis, MIC Determination, and Cytotoxicity Assessment in Mammalian Cells

Published on: May 22, 2026

Related Experiment Videos

Last Updated: Aug 29, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

Identification of Potential Anti-TB Candidates: A Step-by-Step Guide to Synthesis, MIC Determination, and Cytotoxicity Assessment in Mammalian Cells
10:24

Identification of Potential Anti-TB Candidates: A Step-by-Step Guide to Synthesis, MIC Determination, and Cytotoxicity Assessment in Mammalian Cells

Published on: May 22, 2026

Related Concept Videos

Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

Articles linked to this work by shared authors, journal, and citation graph.

[Optimization of Ecological Network in the Guangdong-Hong Kong-Macao Greater Bay Area Based on Ecosystem Service Trade-offs and Complex Network Theory].

Huan jing ke xue= Huanjing kexue·2026

Two-Step Cascade Process for Efficient Isolation of Cellulose from Sugarcane Trash.

Molecules (Basel, Switzerland)·2026

Identification of Entacapone as a Novel β-Arrestin 1 Biased Antagonist of CXCR7.

Molecules (Basel, Switzerland)·2026

Phosphorylation of VpCAMTA3 by VpCDPK13 enhances cold tolerance in grapevine.

Horticulture research·2026

A phosphorylation‑independent monoclonal antibody improves detection of TDP‑43 pathology across frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and limbic predominant age related TDP‑43 encephalopathy neuropathological change.

Journal of neuropathology and experimental neurology·2026

Magneto-NIR-II-Programmed Cascade Nanozymes Unlocking Blood-Brain Barrier Translocation and Autophagic Resistance in Glioblastoma.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Reactivation of an inert 15-mer antimicrobial peptide by truncation-directed i, i + 7 lactam cyclization.

Bioorganic & medicinal chemistry letters·2026

Semi-synthesis and activity study of α-mangostin ether derivatives bearing N-heterocyclic side chains as multitarget-directed ligands against AD.

Bioorganic & medicinal chemistry letters·2026

Caffeic acid phenethyl ester derivatives inhibit glyoxalase I activity and induce cell death in cultured cancer cell lines.

Bioorganic & medicinal chemistry letters·2026

Synthesis, computational and in vitro anti-tubercular activity studies of thiadiazole-linked pyridazinone derivatives.

Bioorganic & medicinal chemistry letters·2026

Design, synthesis, and evaluation of novel 5-aminolevulinic acid and 3-hydroxypyridinone conjugates for enhanced photodynamic therapy in triple-negative breast cancer.

Bioorganic & medicinal chemistry letters·2026

Synthesis and antimalarial activity of novel C30-aminated betulin derivatives.

Bioorganic & medicinal chemistry letters·2026

Five New Iridoids From the Leaves of Viburnum macrocephalum f. macrocephalum and Their Free Radical Scavenging Activity.

Chemistry & biodiversity·2026

Nanovesicle-formulated Sterculia coccinea Jack (hantap) leaf extract: Estrogen receptor-alpha molecular docking and cytotoxicity in Michigan Cancer Foundation-7 cells.

Journal of advanced pharmaceutical technology & research·2026

Tissue-specific untargeted 1H-NMR metabolomics reveals no adverse metabolic effects of daily intrabuccal cannabidiol (CBD) in healthy mice.

Frontiers in pharmacology·2026

Chemical profiling, biological evaluation, and QSAR-informed metabolite prioritization of Hypericum ekerii: a first report on antioxidant, enzyme inhibitory, and cytotoxic activities.

RSC advances·2026

Pharmacological activities of Xanthosoma sagittifolium (L.) Schott and Corchorus olitorius L. extracts in uterine leiomyoma: evidence from in vitro and in vivo approaches.

Frontiers in pharmacology·2026

Exploring the Interaction of Flavonoids Baicalein and Scutellarein With Human Serum Albumin: Spectroscopic and Computational Study.

ChemPlusChem·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us