Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vancomycin disulfide derivatives as antibacterial agents.

YongQi Mu1, Matthew Nodwell, John L Pace

  • 1Theravance, Inc, 901 Gateway Blvd, South San Francisco, CA 94080, USA. ymu@theravance.com

Bioorganic & Medicinal Chemistry Letters
|January 27, 2004
PubMed
Summary

New vancomycin analogues with disulfide bonds in lipid chains were created to improve drug properties. These compounds maintain strong antibacterial effects against resistant bacteria while showing reduced accumulation in organs like the kidney and liver.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Webervirus</i> phages exploit capsule- and O-antigen-targeting receptor-binding proteins to access diverse <i>Klebsiella pneumoniae</i> hosts.

mBio·2026
Same author

Synergistic Inhibition of <i>Acinetobacter baumannii</i> Biofilm Formation and Reduction of Lung Inflammation In Vivo by Combination of α-Pinene and Meropenem.

Microorganisms·2026
Same author

Synergistic role of oxygen vacancies and heterojunction interface in g-C<sub>3</sub>N<sub>4</sub>/H<sub>2</sub>-annealed SrWO<sub>4</sub> for enhanced photocatalytic H<sub>2</sub> production.

Journal of colloid and interface science·2026
Same author

The RAvIN Platform: A Noncarbohydrate Platform for Oligonucleotide Synthesis.

Journal of the American Chemical Society·2026
Same author

The Effect of Portion Size Interventions on Energy Intake and Risk of Obesity in School-Aged Children: A Systematic Review and Meta-Analysis.

Nutrients·2025
Same author

A gram-scale synthesis of β-L-carbafucose for engineering antibody glycans.

Communications chemistry·2025

Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Drug Discovery

Background:

  • Vancomycin is a critical antibiotic for treating serious Gram-positive bacterial infections.
  • Increasing antibiotic resistance necessitates the development of novel therapeutic agents.
  • Optimizing pharmacokinetic profiles (Absorption, Distribution, Metabolism, and Excretion - ADME) is crucial for effective drug therapy.

Purpose of the Study:

  • To design and synthesize novel lipidated vancomycin analogues.
  • To incorporate disulfide bonds within the lipid chains to modulate ADME properties.
  • To evaluate the antibacterial activity and tissue distribution of these new analogues.

Main Methods:

  • Synthesis of a series of lipidated vancomycin analogues featuring disulfide bonds.

Related Experiment Videos

  • In vitro testing against a panel of resistant bacterial strains.
  • In vivo studies to assess tissue accumulation in organs such as the kidney and liver.

    • Main Results:

    • The synthesized vancomycin analogues demonstrated significant antibacterial potency against resistant organisms.
    • These compounds exhibited favorable ADME profiles.
    • Low accumulation of the analogues was observed in key tissues, including the kidney and liver.

    Conclusions:

    • Lipidated vancomycin analogues with disulfide bonds represent a promising strategy for developing new antibiotics.
    • These compounds offer a potential solution for combating resistant bacterial infections with improved safety profiles.
    • Further investigation into these analogues could lead to advanced therapeutic options for challenging infections.