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Interleukin-6 in the aging brain.

J P Godbout1, R W Johnson

  • 1Laboratory of Integrative Biology, Department of Animal Sciences, University of Illinois at Urbana-Champaign, 61801, USA.

Journal of Neuroimmunology
|January 27, 2004
PubMed
Summary
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Interleukin-6 (IL-6) increases in the aging brain, potentially impacting cognitive functions and contributing to age-related changes. This cytokine may influence the neurophysiology of aging.

Area of Science:

  • Neuroscience
  • Immunology
  • Aging Research

Background:

  • Interleukin-6 (IL-6) is a cytokine expressed by astrocytes, microglia, and neurons in the brain.
  • Brain IL-6 has been linked to reduced food intake, impaired memory and learning, neurodegeneration, and exacerbated sickness behavior.
  • Elevated IL-6 levels in the brains of healthy aged animals suggest a role in age-related neurophysiological changes.

Purpose of the Study:

  • To discuss emerging evidence of age-related increases in brain IL-6.
  • To explore the potential impact of this inflammatory cytokine on aspects of successful aging.

Main Methods:

  • This report is a brief discussion based on recent evidence.
  • Literature review and synthesis of existing research findings.

Related Experiment Videos

Main Results:

  • Recent evidence indicates an increase in IL-6 levels within the brain of healthy aged animals.
  • This age-related increase suggests IL-6 may be a factor in the neurophysiological manifestations of aging.

Conclusions:

  • An age-related increase in brain IL-6 is supported by recent findings.
  • Interleukin-6 may play a significant role in the neuroinflammatory processes associated with aging and influence the trajectory of successful aging.