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Related Experiment Videos

White-matter diffusion anisotropy after chemo-irradiation: a statistical parametric mapping study and histogram

Lucullus H T Leung1, Gaik Cheng Ooi, Dora L W Kwong

  • 1Department of Clinical Oncology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.

Neuroimage
|January 27, 2004
PubMed
Summary

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Cranial irradiation and chemotherapy in medulloblastoma survivors can cause white matter injury. Quantitative analysis of fractional anisotropy (FA) maps can detect and monitor this treatment-induced neurotoxicity in children.

Area of Science:

  • Neuroimaging
  • Pediatric Oncology
  • Radiology

Background:

  • Cranial irradiation and chemotherapy are standard treatments for medulloblastoma.
  • These treatments can lead to long-term neurotoxicity, particularly affecting white matter (WM).
  • Early detection and monitoring of WM injury are crucial for managing treatment-induced neurotoxicity.

Purpose of the Study:

  • To evaluate white-matter (WM) diffusion anisotropy in medulloblastoma survivors post-treatment.
  • To identify quantitative indices for detecting and monitoring treatment-induced WM injury.
  • To assess the utility of voxel-based analysis and fractional anisotropy (FA) histogram indices.

Main Methods:

  • Voxel-based analysis using SPM99 with Familywise Error (FWE) and False Discovery Rate (FDR) corrections.

Related Experiment Videos

  • Fractional anisotropy (FA) histogram analysis, including mean FA, peak height, and peak location.
  • Two-sample t-tests were employed for statistical comparisons between patient and control groups.

    • Main Results:

    • FWE-corrected analysis revealed reduced anisotropy in periventricular WM.
    • FDR-corrected analysis identified multiple clusters of reduced anisotropy in WM regions (periventricular, corpus callosum, corona radiata).
    • FA histogram analysis showed significant reductions in mean FA and peak location, and an increase in peak height in patients compared to controls.

    Conclusions:

    • Quantifying FA using histogram analysis is a viable method to characterize WM changes after cranial irradiation and chemotherapy.
    • This approach holds potential for detecting and monitoring treatment-induced neurotoxicity in pediatric cancer survivors.
    • The findings highlight the sensitivity of diffusion anisotropy measures in assessing radiation and chemotherapy-related WM injury.