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Aminopeptidases and angiogenesis.
1Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. y-sato@idac.tohoku.ac.jp
Endothelium : Journal of Endothelial Cell Research
|January 27, 2004
Summary
Aminopeptidases, enzymes regulating protein modification, are increasingly recognized for their crucial roles in angiogenesis, the formation of new blood vessels. This review explores the specific functions of methionine aminopeptidase type 2, aminopeptidase N, and adipocyte-derived leucine aminopeptidase in this vital process.
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Biology
Background:
- Proteases like matrix metalloproteinases and plasminogen activators are established regulators of angiogenesis.
- Emerging evidence highlights the involvement of aminopeptidases in angiogenesis.
- Aminopeptidases are critical for N-terminal protein/peptide modifications, influencing maturation, activation, and degradation.
Purpose of the Study:
- To review the specific roles of key aminopeptidases in the process of angiogenesis.
- To elucidate the mechanisms by which aminopeptidases contribute to blood vessel formation.
Main Methods:
- Literature review of studies investigating aminopeptidases and angiogenesis.
- Analysis of the known functions of specific aminopeptidases in cellular processes related to angiogenesis.
Main Results:
- Identified three primary aminopeptidases involved: methionine aminopeptidase type 2, aminopeptidase N, and adipocyte-derived leucine aminopeptidase/puromycin-insensitive leucyl-specific aminopeptidase.
- These enzymes modulate protein activity and availability essential for angiogenic processes.
Conclusions:
- Aminopeptidases are significant, yet often overlooked, regulators of angiogenesis.
- Further research into these enzymes could reveal novel therapeutic targets for angiogenesis-related diseases.